Based on the published studies on the endocannabinoid system, its ligands, receptors, mechanism of action and signalling has led to research showing the therapeutic applications of CBD in dogs. The main applications ported include osteoarthritis-associated pain, aggressive behavior, and epilepsy. In dogs with idiopathic epilepsy, CBD appears to alleviate seizure frequency. A study by Brioschi et al., showed that CBD relieved osteoarthritic (OA) pain and improved life quality in dogs, allowing a reduction of other drugs’ dosage and thus minimizing their potential side effects. The main route of administration of CBD in animals is oral; several bioavailability studies reported how CBD availability when administered orally is very low, with an average value of 10%, presumably due to a high first-pass effect through the liver, where it also gives its major adverse effects. The CBD has been tested in different human, animal and in vitro models in order to determine its efficacy in pain modulation based on the interaction with CB1 and CB2 receptors.
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Potential future applications of CBD in Veterinary – what can we expect or hope for
