In the constantly evolving scenario of Cybercrime, two main aspects reveal an increased urgency of tackling the challenges posed by Cyber Threats. The first is the fast scalability of cyber targets, which have changed in the recent few years from single and specific computers to distributed systems and networks of companies. The second one is represented by the nature of the Cyber Threat, no longer identified solely with isolated and independent criminals, but increasingly represented by specialized forces of national states. Most recent news on Cybersecurity incidents targeting specifically the production and the distribution of Covid-19 vaccines show that this trend is escalating very rapidly and cybersecurity culture still lacks of effectiveness: the vast majority of the companies that could be now considered as new cyber targets (e.g. third party suppliers, distributors, and so on) do not have a clear plan for dealing with cyberattacks.